What are Pyrogens and Endotoxins…and How Can They Be Controlled in a Cleanroom

Often, we use the terms’ bacterial endotoxin’ and ‘pyrogen’ interchangeably. They refer to phospholipid-polysaccharides (also termed lipopolysaccharides, or LPS). And there’s a chance that these pyrogens may be released from decaying Gram-negative bacteria such as E. coli. Following cell death, these complex macromolecules emanate from compromised outer cell walls. If unchecked, it can induce and cause harm.